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The 4 Chemicals Secretly Controlling Your Motivation and Mood

TJ Power is the lead neuroscientist at The DOSE Lab and the Sunday Times bestselling author of The DOSE Effect. He created the DOSE framework, which shows how sedentary and digital lifestyles affect mental well being and performance. TJ has trained more than 75,000 people at organizations that include Oxford University, Amazon, and the NHS. He is known for helping people rebalance their brain chemistry and unlock peak mental health in the digital age.


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Did you know four brain chemicals secretly control your motivation, mood, and mental energy every single day?

In this episode, Jim sits down with neuroscientist and bestselling author TJ Power to break down the DOSE Effect. It is a science backed framework for activating the four key neurochemicals that shape your daily experience: Dopamine, Oxytocin, Serotonin, and Endorphins.

TJ shares how our modern digital lifestyles are draining these natural feel good chemicals and how you can rebalance them through small, evidence based habits. You will learn the difference between natural and artificial dopamine, how to boost oxytocin through real human connection, the serotonin and sunlight link that stabilizes your mood, and the surprising power of endorphins to calm stress.

You will also hear why technology is hijacking your motivation system, how to design your environment to protect your brain, and a simple daily ritual to reset your chemistry in under five minutes.

By the end, you will have a clear roadmap to upgrade your focus, energy, and emotional balance without relying on caffeine, willpower, or scrolling.

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Books mentioned:
The DOSE Effect by TJ Power

Products mentioned:
Timeline Mitopure timeline.com/kwik

Topics mentioned:
Flow State and dopamine
Glutamate and decision fatigue
Sunlight and serotonin
Endorphins and physical stress response

Apps mentioned:
Roots screen time blocker

TJ Power

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**This week’s show notes are taken from the video — enjoy!**

[01:57] What is ‘DOSE’? and what these four neurochemicals really do for your brain
[02:59] D = Dopamine: why effortless rewards kill motivation
[04:30] O = Oxytocin: the connection chemical
[05:44] S = Serotonin: sunlight, mood stability, and the “sunlight before social media” rule
[06:58] E = Endorphins: simple daily movement to relieve stress and improve resilience
[08:24] Technology’s dopamine trap, and how to set healthy boundaries
[12:26] The “fifth chemical” glutamate and how decision overload causes brain fog
[14:08] How to regain your motivation and energy
[19:36] Morning and evening routines for running your neurochemicals naturally

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